A term male infant of 39 weeks gestation has profound cyanosis at 4 hours of age which has not responded to 100% supplemental oxygen and conventional mechanical ventilation. The chest radiograph is largely clear. There is a 12% difference between pre- and post-ductal oxygen saturations. Which investigation is the single most appropriate to confirm a diagnosis of PPHN?
A 24-week infant receiving oxygen is being managed on the neonatal unit. The nursing team asks what saturation target range and alarm limits to use. Which combination is the most appropriate according to the 2025 European Consensus Guideline on Management of RDS?
A male infant of 38 weeks gestation with severe meconium aspiration syndrome is intubated and ventilated with conventional mechanical ventilation. His current settings are FiOâ‚‚ 1.0 and mean airway pressure 14 cmHâ‚‚O. A postductal arterial blood gas shows PaOâ‚‚ 40 mmHg. Echocardiography confirms PPHN with no structural heart disease. He is being cared for in a tertiary centre with full access to HFOV, iNO and ECMO. Which is the single most appropriate next step in management?
